ETHOSUXIMIDE

ETHOSUXIMIDE

Brand Names : Atysmall; Capitus; Emeside; Epileo Petilmal; Ethymal; Mesentol; Pemal; Peptinimid; Petinimid; Petinidan; Pyknolepsinum; Simatin; Succimal; Suxilep; Suximal; Suxinutin; Thilopemal; Zarontin.

Ethosuximide, m.p. 64-65°, is considered as a 2, 5-pyrrolidinedione. The hydrogen atom of the imide group is acidic and can be replaced by metals or alkyl groups. It is freely soluble in water, alcohol, chloroform and ether. It condenses with resorcinol in the presence of concentrated sulphuric acid to yield aphthaleinlike compound. Its sodium salt has a bright green fluorescence. It is stored in airtight containers.



Uses : Ethosuximide is effective in pure petit mal but less effective in mixed petit mal.



Side Effect

Gastro-intestinal side-effects including nausea, vomiting. anorexia, gastric upset and abdominal pain occur with ethosuxinide.



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