PIPERAZINE

PIPERAZINE

Brand Names : Worm-Away; Wurmirazin; Lumbrical; Arthriticin; Dispermine.


It is prepared by the actionofalcoholic ammonia on ethylene chloride (Hofmann amine synthesis); by catalytic deamination of diethylenetriamine and of ethylenediamine, and by cyclization of ethylene diamine by the action of heat on its hydrochloride.

Piperazine is a crystalline solid, m.p. 106°, salty taste, abserbs water and CO, from air and freely soluble in water, glycerol and glycols. It crystallizes as leaflets from alcohol and as a low melting hexahydrate from wat  It combines with two equivalents of acids. It is a stronger base than ammonia. It has all the expected properties of a secondary amine. It is stored in airtight containers.

Uses


It is used as an anthelmintic for the treatment of pinwoĊˆmis and roundworms in children and adults. Piperazine is usually administered as the citrate or phosphate, but dosage is generally stated in terms of the hexahydrate.

Adverse Effect



Serious adverse effects are rare with piperazine. Overdose may cause nausea, vomiting, diarrhoea, abdominal pain, headache and urticaria.




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