WARFARIN
WARFARIN Brand Names : Compound 42; WARF compound-42; Athrombine-K; Coumadin. Warfarin, m.p. 161°, is a crystalline compound soluble in acetone and dioxane; moderately soluble in methanol, ethanol, isopropanol and some oils; freely soluble in alkaline aqueous solutions, practically insoluble in water, benzene, and cyclohexane. Warfarin has an acidic enol which forms metallic salts and an acetate, m.p. l l 7-l 18°, and a ketone which forms an oxime, m.p. 182-183°, and a 2,4- dinitrophenylhydrazone; stored in well-closed containers and protected from light. Warfarin sodium (Brand Names : Marevan; Prothromadin; Tintorane: Warfilone: Waran) is slightly bitter, white odourless amorphous or crystalline powder. It is decolourized by light; freely soluble in water and alcohol; very slightly soluble in chloroform and ether. Uses: Warfarin is an anticoagulant which depresses the hepatic vitamin K-dependent synthesis. It is used in the prevention and management of deep-vein thrombos...