WARFARIN

WARFARIN

Brand Names : Compound 42; WARF compound-42; Athrombine-K; Coumadin.

Warfarin, m.p. 161°, is a crystalline compound soluble in acetone and dioxane; moderately soluble in methanol, ethanol, isopropanol and some oils; freely soluble in alkaline aqueous solutions, practically insoluble in water, benzene, and cyclohexane. Warfarin has an acidic enol which forms metallic salts and an acetate, m.p. l l 7-l 18°, and a ketone which forms an oxime, m.p. 182-183°, and a 2,4- dinitrophenylhydrazone; stored in well-closed containers and protected from light.
Warfarin sodium (Brand Names : Marevan; Prothromadin; Tintorane: Warfilone: Waran) is slightly bitter, white odourless amorphous or crystalline powder. It is decolourized by light; freely soluble in water and alcohol; very slightly soluble in chloroform and ether.
Uses: Warfarin is an anticoagulant which depresses the hepatic vitamin K-dependent synthesis. It is used in the prevention and management of deep-vein thrombosis or pulmonary embolism, in myocardial infraction, stroke and transient ischaemic attacks.

Side Effect
The major risk from warfarin therapy is of haemorrhage from any organ of the body. Skin necrosis is occasionally observed. A purple discolouration of the toes has sometimes been occurred. Other effects include alopecia, fever, nausea, vomiting, diarrhoea, hypersensitivity reactions, priapism, and skin reactions.




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