AMPICILLIN

Brand Names :
Ampicillin A, BRL 1341: P 50; Ay 6108; Adobacillin; Alpen; Amfipen; Ampi-Bol; Bonapicillin; Grampenil; Guicitrina; Copharcilin; Nuvapen; Synpenin; Viccillin: Ultrabion; Ampipenin; Amplisom; Ampimed; Ampy-Penyl; Totalciclina; Amipenix S; Amblosin; Ampicin; Amplital; Austrapeen; Binotal; Britacil; Doktacillin; Marisilan; Pen-Bristol; Penbritin; Penbrock; Penicline; Pentrex; Pentrexyl; Ponecil; Polycillin; Ql Damp; Tokiocillin;


Ampicillin is a white or slightly buff-coloured odourless crystalline powder . Its monohydrate, known as Redicilin, m.p. 2O2° (decomp), is sparingly soluble in water; practically insoluble in alcohol, acetone, chloroform, ether, and fixed oils. It dissolves in dilute solutions of acids and alkali hydroxides. This antibiotic is active against the same gram-positive organisms that are susceptible to other penicillins, and it is more active against Some gram-negative bacteria and enterococcal infections.



Ampicillin is not resistant to penicillinase, and it produces the allergic reactions and other unwanted effects that are found in penicillin sensitive patients.

Anhydrous form (Brand Narsies : Ampicillin B; Omnipen; Obicilina) occurs in crystalline form, m.p. 199-202° (dec). compared to hydrated form, anhydrous compound is more stable on storage, less soluble in water, dimethyl sulphoxide, and has a different crystal structure. It can be converted to ampicillin A by hydration. Ampicillin is stored at a temperature not exceeding 30° in airtight containers.

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