CEPHALORININE



Brand Names: Ceflorin; Cepaloridin; Cer; Faredina; Cefaloridin; Ceporan; Ceporin; Cilifor; Intrasporin; Keflodin; Keflordin (obsolete); Lloncefal; Sefacin; Cepalorin; Deflorin; Kefspor; Loridine; Alipornia; Ampligram; Floridin.

When cephalosporin C produced by the growth of certain strains of various cepalosporium species, or 7-ACA is reacted with organic bases such as pyridine, a nucleophilic displacement of the acetyloxygroup takes place. The pyridinium compound so obtained is more potent than its acetoxyl analogue.

Cephaloridine is a white crystalline powder. It is soluble in water, slightly soluble in alcohol; practically insoluble in chloroform and ether. It is decolourized when exposed to light. It deteriorates rapidly in aqueous solutions which should be used within 24 hours of their preparation when stored at 2° to 15°C. It is stored in airtight containers at a temperature of 8° to 15°C and protected from light.

Uses
 Cephaloridine is :)the treatment of infections of skin, suft tissues, bone, joint, respiratory and urinary tracts. Its use, however, has been limited by nephrotoxicity.

Adverse Effect

Allergic reactions, including skin rashes, urticaria, eosinophilia, fever reactions resembling serum sickness and anaphylaxis may occur in patients receiving cephaloridine. It is considered to be the most nephrotoxic of the cephalosporins, and for this reason is seldom used. Acute and fatal renal failure may occur




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