ETHIONAMIDE

ETHIONAMIDE

Brand Names : Amidazine; Ethioniamide; Bayer 5312; Nisotin; 1314 Th; Trecator; Trescatyl, Aetina; Ethimide; Iridocin; Tio-Mid

Ethionamide can be obtained by addition of hydrogen sulphide to the corresponding nitrite in the presence of triethanolamine.

The drug occurs as a yellow, crystalline substance, m.p. 164-166, very sparingly soluble in water and ether; sparingly soluble in methanol, ethanol and propylene glycol; soluble in hot acetone and dichloroethane; freely soluble in pyridine. It darkens on exposure to light, with a slight sulphur-like odour. A 1% suspension in water has a pH of 6 to 7. It is stored in airtight container .

Uses

Ethionamide is a substituted thioamide of isonicotinic acid which has been used with other antituberculous agents for the treatment of tuberculosis, generally when resistance to primary agents has developed. It is a secondary drug in the chemotherapy of tuberculosis and is claimed to be five times less toxic .

Many patients cannot tolerate therapeutic doses of ethionamide. The most common adverse side-effects are gastrointestinal disorders, excessive salivation, metallic taste, dizziness, headache, etc.





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