FOLIC ACID

FOLIC ACID




Folic acid is a hematopoietic vitamin present in free or combined with one or more additional molecules of L (+)- glutamic acid in liver, kidney, mushrooms, spinach, yeast, green leaves, and grasses. It is the active principle required for the growth of a Streptococcus lactis under specific conditions.


Folic acid is ayellow to orange brown, odourless, crystalline powder. it is practically insoluble in water and most organic solvents.


It darkens and chars from about 250°. Injectable solutions are prepared by dissolving folic acid in normal sodium bicarbonate solution or by preparing solutions of the sodium or methylglucamine salt. 


A suspension of 1 g folic acid in 10 ml water has a pH of 4.0-4.8. Aqueous solutions of folic acid or its sodium salt are stable to air. Folic acid in the dry state or in very dilute solutions is decomposed readily by sunlight or ultraviolet light. Folic acid in foods is destroyed more readily by cooking than are the other water soluble vitamins. It is kept in wellclosed containers and protected from light.





Uses: Folic acid is a member of the vitamin B group. Folic acid is reduced in the body to tetrahydrofolate, which is a co-enzyme for the synthesis of DNA. Its deficiency produces megaloblastic anaemia.




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