INDIGOTIN DISULPHONATE SODIUM (INDIGO CARMINE)

INDIGOTIN DISULPHONATE SODIUM (INDIGO CARMINE)

Brand Names : Sodium indigotin disulphonate; Soluble indigo blue; Indigotine; Acid Blue 74; CI. Acid Blue 74; C.I. Food Blue l; FD&C Blue No-2. C.I. 73015, Blue X; Ceruleinum.

Indigo carmine is the sodium salt of a disulphonic acid derived from indigo. Indigo is a natural blue dye which has been obtained from the indigo plant (Indigofera tinctoria Linn; Leguminosae). It can be prepared by condensing two molecules . of phenylglycine-O-carboxylic acid and then sulphonating the product.


Indigo carmine is a purplish-blue powder or blue granules with a coppery lustre. It is soluble in water (1 in 100); slightly soluble in alcohol; practically insoluble in most other organic solvent. Its solutions have a blue or bluish-purple colour. It is also marketed as a paste with water, the dye contents varying according to specification or requirement of the user. The colour is due to resonance associated with the chromophore O=C-C=C-C=O which is discharged by alkaline reducing agents and by oxidizing agents like nitric acid, chlorates, etc.

Indigo carmine is very sensitive to light and the colour of the aqueous solution fades on standing. Its solutions may be sterilized by autoclaving.

Uses: Indigo carmine is used as a dye for testing : enal (kidney) function; to locate the ureteral orifices; in colouring nylon surgical sutures; as a reagent for the detection of nitrate, chlorate, and in testing milk. It has alsc been used as a marker dye to aid urological and other procedures: as a food colour and as a blue dye in medicinal preparations. Normally, it appears in urine in 10 minutes, and about 10 per cent of it is eliminated during the first hour.

Side Effect
Indigo carmine may cause nausea, vomiting, hypertension and bradycardia, and sometimes allergic reactions such as skin rash, prutitus and bronchoconstriction. Officia Indigo Carmine, I.P. Indigotindisulfonate Sodium Injection, U.S.P.




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