IODO-CHLORHYDROXYQUIN

IODOCHLORHYDROXYQUIN

Brand Names : Chloroiodoquin, Iodochlorohydroxyquinoline; Iodochloroxyquinoline; Quinoform, Amebil; Alchoquin; Amoenol; Bactol; Barquinol; Budoform; Chinoform; Clioquinol; Cliquinol; | Eczecidin; Enteroquinol: Entero-Septol; Entero-Vioform: Enterozol; Entrokin; Hi-Enterol; Iodoenterol; Nioform; Quinambicide; Rometin Vioform.

It is a halogenated derivative of 8-hydroxy- HO quinoline. An aqueous solution of an alkali salt I N of 5-chloro-8-hydroxyquinoline (prepared by a N Skraup's quinoline synthesis) is iodated using  potassium iodide and a hypochlorite. The activating phenolic group directs the iodine into  the ortho position in the homocyclic ring.

The compound consists of spongy, brownish-yellow, bulky powder with a slight, characteristic odour, m.p. 178-180° (dec). It darkens on exposure to light. It is practically insoluble in water or alcohol but dissolves in hot ethyl acetate and in boiling acetic acid. It is decomposed by heating with dilute hydrochloric acid, more easily with concentrated sulphuric acid, eliminating vapours of iodine. The drug is stored in airtight containers and protected from light .

Uses

 Iodochlorhydfoxyquin has been used as topical intestinal anti-infective, and anti-amoebic, taken orally. Oral preparations have now been withdrawn worldwide because of neurotoxicity.
Iodochlorhydroxyquin has antibacerial and anti-fungal alc activity and is used in creams and ointments in the treatment of Us skin infections. It is also applied together with a corticosteroid pr in inflammatory skin conditions complicated by bacterial or fungal infection .
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Side effect
The side-effects of the drug are severe irritation, staining of the skin, discolouring of hairs, neurotoxicity and cerebral ha disturbances.



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