OESTRADIOL



Brand Names : Estradiol; Dihydrofollicular hormone; Dihydroxyestrin; Compudose 365; Dihydromenformon; Dimenformon; Diogyn; Femestral; Gynergon, Gynoestryl; Lamdiol; Macrodiol; Ovalhormon; Ovasterol; Ovocyclin; Perlatanol; Primofol; Profoliol; Progynon-DH.


Oestradiol, an important and potent Hc female sex hormone, contains ring A aromatic; the methyl group attached to C-10 is absent and the 3-hydroxyl group is phenolic. 

Naturally, it is formed by the ovary, placenta, testis and possibly by 9 the adrenal cortex. It has been isolated from follicular liquor of sow ovaries (6 mg perton) and from pregnancy urine of mares. It can be prepared by reduction of oestrone. Esters of oestradiol are absorbed more slowly than oestradiol.


Oestradiol, m.p. 173-179°, occurs as white or creamywhite, odourless, hygroscopic crystalline powder. It is practically insoluble in water; soluble in alcohol, chloroform, ether, acetone, dioxane and solutions of alkali hydroxides; sparingly soluble in vegetable oils. It is stored in airtight containers and protected from light.
Oes tradiol benzoate, cypionate, dipropionate, enanthate, hexahydrobenzoate, undecanoate and Valerate are all used as drugs.


Uses: Oestradiol takes part in the development and maintenance of the female sex organs, secondary sex organs i.e. vagina, the fallopian tubes and uterus; the development of breasts, and genital tract and the distribution of hairs. It is used in deficiency states of menopausal syndrome, for the treatment of metastatic prostate cancer and breast cancer of postmenopausal women, for the suppression of lactation.

Side Effect

The side-effects of oestradiol therapy include sodium retention and oedema, nitrogen retention and weight gain, tenderness of the breasts, gynaecomastia in the male, alteration of liver function, jaundice, depression, headache and dizziness.



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