PAROMOMYCIN SULPHATE

PAROMOMYCIN SULPHATE




Brand Names : 1600 Antibiotic; Farmiglucin; Farminosidin; Fi 5853; Gabbromicina: Gabbromycin, Gabbroral: Humatin: Pargonyl: Paramicina; Paricina: Aminosidinum; Sulfuricum: Amminosidina solfato; Catenulin-paromomycin I sulphate; Catenulin sulphate; R 400 sulphate, Neomycine E sulphate.




Paromomycin was isolated in 1959 by Coffey et al. from cultures of Streptomyces rimosus forma paromycinus obtained from Soil from Colombia. The antibiotic is very similar to neomycin, consisting of a mixture of two isomers differing only in the configuration in one of the rings. 


It differs from neomycin in that the 2-deoxystreptamine is linked to 2-deoxy-2-amino-D-glucose instead of neosamine. Paromomycin consists of two isomersparomomycins I and II. The combination of D-glucosamine with deoxystreptamine is obtained by partial hydrolysis of both paromomycins and is called paromamine.



Paromomycin occurs as an amorphous, white powder; soluble in water; moderately soluble in methanol; sparingly soluble in absolute alcohol.



Paromomycin sulphate is a creamy white to light yellow, odourless, hygroscopic powder; very soluble in water; practically insoluble in alcohol, chloroform and ether. It is stored in airtight containers.

Uses

Paromomycin sulphate is an aminoglycoside antibiotic which has been taken orally to treat intestinal amoebiasis, bacterial diarrhoea and for the suppression of the intestinal flora prior to surgery.

ADVERSE EFFECT
It may cause partjál or total deafness, nausea, vomiting and diarrhoea in large doses.



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