PYRAZINAMIDE

PYRAZINAMIDE

Brand Names : Addinamide; D-50; Eprazin , Pezetamid; Pyrafat; Pirilene; Piraldina; Tebrazid; Unipyranamide; Zinamide.
This simple pyrazine derivative can be prepared from quinoxaline by oxidation with permanganate, thermal decomposition of the dicarboxylic acid, and esterification with methanol followed by ammonolysis.
Pyrazinamide occurs as a white crystalline, odourless powder, m.p. 189-191. It is practically insoluble in water and ether; slightly soluble in alcohol and chloroform

Uses
It is used for patients whose tuberculosis is resistant to other drugs.
It causes a significant incidence of liver damage. With doses of 3 g daily up to 15% of patients may show sign of liver damage. Other side-effects are anorexia, nausea, vomiting, arthralgia, malaise, fever, anaemia and dysuria. Pyrazinamide increases reabsorption of urates and should thus be used with care in patients with a history of gout.



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