TESTOSTERONE

TESTOSTERONE


Brand Names : Geno-cristaux Gremy; Malestrone (amps); Orquisteron; Percutacrine Androgenique; Virosterone; Virormone; Testryll; Testrone; Homosteron; Oreton-F; Teslen; Primotest; Primoteston; Sustanon; Mertestate; Testobase.

Testosterone is the principal androgenic hormone of the testes, produced by the interstitial cells. It is isolated in minute amounts from testes, especially bull testes. About 90 to270 mg are present in a ton of testes. It controls the development and maintenance of the male sex organs and male sex characters. There is no natural source rich enough from which testosterone can be prepared. However, it is synthesized on commercial scale from the androgenic excretory products found in stallion urine, cholesterol and sapogenins such as diosgenin and sarsasapogenin. The important intermediate dehydroandrosterone is efficiently transformed into testosterone by a microbial process. Testosterone is only weakly active orally. Testosterone propionate, acetate, cypionate, decanoate, enanthate, isocaproate, heptanoate, cyclopentanepropionate, undecanoate and phenylpropionate are all used in medicine.
Testosterone, m.p. 155°, is a white or creamy-white, odourless, crystals or crystalline powder. It is practically insoluble in water; soluble in alcohol, chloroform, dioxane, vegetable oils and ether; slightly soluble in ethyl oleate. It is protected from light. In underdeveloped or adolescent males, testosterone increases the size of the scortum, phallus, seminal vesicles, and prostate; libido and sexual activity may also be increased.
Testosterone also produces systemic effects, such as an increased retention of nitrogen, calcium, sodium, potassium, chloride, and phosphate. This leads to an increase in skeletal weight, water retention, and increased growth of bone. The skin becomes more vascular and erythropoiesis is increased.

Uses: Testosterone is an androgen used as replacement therapy in male hypogonadal disorders and in adolescent males with delayed puberty. It is usually used as a subcutaneous implant in a dose of 200 to 600 mg. Testosterone esters have been used in postmenopaual breast carcinoma and in Osteoporosis.

Side Effect
The side-effects oftestosterone include increase in nitrogen retention and skeletal weight, oedema, increased vascularity of the skin, hypercalcaemia and increased growth of the bone.





Comments

Post a Comment

Popular posts from this blog

PROPANDID

PROPANDID Brand Names : Bayer-1420; FBA-1420; TH-2 180; WH-5668. Propanidid, b.p. 210-212°, is a pale greenish-yellow viscous liquid with a slight odour. It is very slightly soluble in water; miscible with alcohol, chloroform and  ether. Propanidid has been used as an  intravenous anaesthetic for rapid induction and for maintenance of anaesthesia of short duration
Read more

Vitamin A2

Vitamin A2 Vitamin A2, ( Brand Names : Retinol 2; 3,4-Didehydroretino Dehydroretinol); all trans, m.p. 17-19; 13-cis, m.p. 73-74°. is found in marine fishes of the family Labridae and in turtles. It exhibits chemical, physical and biological properties identical to vitamin A Vitamin A2 has about 40 per cent of the bioactivity of crystalline vitamin A
Read more

RESERPINE

RESERPINE Brand Names : Alserin; Austrapine; Crystoserpine; Eskaserp; Hiserpia; Orticalm; Quiescin; Rau-red; Reserpex; Reserpoid; Rivasin; Roxinoid; Sandril; Sedaraupin; Serfin; Serolfia; Serpanray; Serpasil; Serpasol; Serpate; Serpen; Serpine; Serpiloid. Reserpine is an alkaloid obtained from the roots of certain species of Rauuolfia (Apocynaceae) mainly Rauuvolfia serpentina and R. vomitoria, or by synthesis. It occurs as odourless, small, white or pale buff to slightly yellow coloured crystals or crystalline powder, m. p. 264-265° (decomp). It is very sparingly soluble in water; freely soluble in chloroform, methylene chloride, glacial acetic acid; soluble in benzene and ethylacetate; slightly soluble ܗܘ in acetone, methanol, alcohol, ether and in aqueous solutions of acetic and citric acids. Upon standing most solutions acquire a yellow colour and pronounced fluorescence, especially after the addition of acid or upon exposure to light. It is stored in airtight containers...
Read more