TETRACYCLINE HYDROCHLORIDE

TETRACYCLINE HYDROCHLORIDE

Brand Names : Achro; Achromycin V: Ala Tet; Ambracyn; Artomycin; Cefracycline tablets; Cyclopar; Diacycline; Dumocyclin; Mephiacyclin; Partrex; Quadracycline; Quatrex; Remicyclin; Ricycline; Ro-cycline; Stilciclina; Subamycin; Supramycin; Sustamycin; Tefilin; Teline; Telotrex; Tetrabakat; Tetrabid; Tetrablet; Tetrachel; Tetracompren; Tetra-D; Tetrakap; Tetralution; Tetramavan, Tetramycin; Tetrasol; Tetra-wedel; Topicycline; Totomycin; Triphamycin; Unicin; Unimycin; Vetouamycin-324.

Tetracycline hydrochloride is a yellow, odourless, hygroscopic, crystalline, amphoteric powder. It darkens in moist air when exposed to strong sunlight. It is soluble in water (1 in 1O), alcohol (1 in 100), aqueous alkali hydroxides and garbonate solutions; insoluble in acetone, chloroform and ether Aqueous solutions become turbid on standing due to hydrolysis and precipitation of tetracycline. The potency of tetracycline hydrochloride is reduced in solutions having a pH below 2. It is stored in airtight containers and protected from light.

An insoluble tetracycline phosphate complex (Brand Names : Panmycin Phosphate; Sumycin; Tetradecin Novum; Tetrex; Upcyclin) is made by mixing a solution of tetracycline with a solution of sodium metaphosphate. These agents enhance blood level concentrations over those obtained when tetracycline hydrochloride alone is administered orally.

Uses –

The tetracycline has a wide spectrum of activity and is used in the treatment of a large number of infections such as rickettsial infections, including typhus, Rocky Mountain spotted fever, and Q fever; chlamydial infections, including psittacosis, lymphogranuloma, venereum, trachoma, and inclusion conjunctivities; and mycoplasmal infections, especially caused by Mycoplasma pneumoniae. Tetracyclines are used in the treatment ofbrucellosis, plague, tularaemia, chronic bronchitis, chancroid, granuloma inguinale, urinary-tract infections such as non-specific urethritis, malabsorption syndromes such as tropical sprue and Whipple's disease, cholera in conjunction with fluid, relapsing fever, leptospirosis, in early stages of Lyme disease, balantidiasis and chlamydial infections of the  eye

Side Effect
The side-effects of tetracycline include gastro-intes disorders, nausea, vomiting, diarrhoea, irritation of mucosa, Oesophageal ulceration, hepatotoxicity, allergic oesophageal ulceration, hepatotoxicity, allergic reactions, etc.






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