THIACETAZONE

THIACETAZONE

Brand Names: Thibone, Thioacetazone; TbI/698, Amithiozone; Sdt 1041; RP 42O7; Conteben; Thizone; Norakol: Thionicid: Domakol; Aktivan; Ambathizone; Seroden; Benthiozone: Berkazon; Diasan; Ilbion; Tebalon; Siocarbazone; Tibicur: Thiomicid; Tibion; Tibione; Tebethion; Panrone; Thioparamizone; Myvizone; Thiobicina; Tubercazon; Berculon; Antib; Neustab; Nuclon, Argentinian; Livazone; Benzothiozon; Parazone; Tebezon: Thiotebezin; Thiocarbazil; Thiocarone; Thiosecolo.

It forms minute , pale yellow crystals from alcohol . Taste is bitter, m.p. 225-230 (dec); darkens on exposure to light. It is soluble in hot alcohol; very sparingly soluble in cold alcohol; insoluble in ter, acetone, benzene, carbon tetrachloride, chloroform, carbon disulphide and petroleum ether.
Uses :

Thiacetazone is used in the primary treatment of pulmonary tuberculosis with isoniazid supplemented in the initial phase of treatment, with streptomycin. It is also used in the treatment of leprosy in daily doses similar to those used in tuberculosis.
Gastro-intestinal disorders, hypersensitivity reactions, rashes, and vertigo are the most common side-effects of thletion


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