THROMBIN

THROMBIN





Thrombin is an enzyme. serine proteinase. present in blood plasma in the form of a precursor. prothrombin. Its molecular weight is about 33,580. It plays a central part in the mechanism of blood coagulation by converting the soluble plasma protein, fibrinogen, into insoluble fibrin. Bovine thrombin consists of two polypeptide chains, designated as A and B. The Achain has 49 amino acid residues. It is bound by a disulphide bridge to the B chain which contains about 265 residues and carbohydrate. The prothrombinfraction is prepared by a suitable fractionation technique. The prothrombin is converted into thrombin in solution by the addition of calcium ions and thromboplastin. Thrombin is a white or greyish, amorphous substance.





Uses: Thrombin is a local haemostatic used topically to control haemorrhage from puncture sites or from capillary oozing in surgery.



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