VITAMINE – E

VITAMINE – E

Brand Names : o-Tocopherol; 5,7,8-Trimethyltocol; Antisterility Vitamin; Eprolin-S; Epsilan; Ephynal; Syntopherol; E-Vimin; Evipherol: Etavit; Phytogermine; Esorb; Profecundin; Tokopharm; Viteolin; Vascuals; Covitol; Evion.


Vitamin E, m.p. 2-4°, b.p. 200-22O, contains various forms of a-tocopherol. It is present in highest concentrations (0.1- 0.3%) in wheat germ, corn, sunflower seed, rape seed, soyabean oils, alfalfa and lettuce. Natural O-tocopherol is usually found with B-and Y-tocopherols. It is a clear, slightly greenish-yellow, odourless, viscous oily liquid. It is practically insoluble in water; freely soluble in alcohol, acetone, chloroform, ether and fixed oils. They are stable to heat in the absence of oxygen, stable to strong acids and visible light, but unstable to UV light, alkalies and oxidation. The tocopherols are antioxidants, but they are destroyed by rancid fats. The esters of the tocopherols are more stable than the free alcohols. Vitamin E is slowly oxidized by atmospheric oxygen, rapidly by ferric and silver salts.


Uses: Vitamin E acts as an antioxidant for certain fats and is involved in metabolic reactions. Its deficiency leads to neurological syndromes.

Adverse Effect

Large doses may cause diarrhoea, abdominal pain, fatigue and weakness. Contact dermititis has occurred following topical application.




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