ACETYLDIGITOXIN

Brand Name: Acylanid.

Acetyldigitoxin is obtained by enzymatic hydrolysis of lanatoside A. It is composed of the aglycone digitoxigenin and 3 molecules of digitoxose, to one of which an acetyl group is attached. Acetyldigitoxin-α differs from acetyldigitoxin-β in the position of the acetyl group. The β-form is obtained either by splitting off the glucose residue from lanatoside-A by means of enzymes, or by extraction from the leaves of Digitalis ferruginea (Fam. Scrophulariacae).


Acetyldigitoxin, m.p. 217-221°, is a white microcrystalline hygroscopic powder which is slightly soluble in chloroform and water but is more liposoluble. Akcoholic or hydroakcoholic solutions slowly lose the acetyl group by hydrolysis.

Acetyldigitoxin is absorbed equally when taken orally. It is less toxic and more safe than digitoxin. It is dissipated twice as fast as digitoxin.


Uses: Acetyldigitoxin is a cardiotonic agent.


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