AMITRIPTYLNE

Brand Names o : Ro - 4- 1575; Triptisol; Tryptanol; Sarotex; Seroten; Laroxyl; Redomex; Adepril.

Amitriptyline is prepared from ch co, con (CH3)2 dibenzocycloheptenone. The ketone is synthesized by condensation of phthalic anhydride with phenylacetic acid to give  enzalphthalide, which on reduction yields 2phenethylbenzoic acid; this is converted to the acid chloride, which on treatment with aluminium chloride undergoes cyclization. The ketone is reacted with the  appropriate Grignard reagent, followed by hydrolysis of the complex and dehydration using acetyl chloride to get amitriptyline.

Amitriptyline hydrochloride (Brand Names : Amitid; Amitril; Deprex; Domical Elavill; Endep; Lentizol; Miketorin; Saroten; Tryptizol) is an odourless, colourless or white powder. It is soluble in water (1 in 1), alcohol (1 in 1.5) chloroform (1 in 2) and methanol (1 in 1); practically insoluble in ether; m.p. 196-197* stored in a well-closed container.

Uses :

Amitriptyline is a tricyclic antidepressant used in the treatment of mental depression, and for nocturnal enuresis in children.

Side Effect


Many side-effects of amitriptyline and other tricyclic antidepressants are caused by their antimuscarinic action. These include dry mouth, sour or metallic taste, constipation, urinary retention, blurred vision and disturbances in accommodation, palpitation, tachycardia, and impotence. Many other side effects have also occurred.

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