AZATHOPRINE

Brand Names: Azothioprine Azanin; Imuran; Imurel.



Azathioprine occurs as pale yellow 3 NSN N odourless crystals or powder. It is practically insoluble in water, alcohol and chloroform; sparingly soluble in dilute mineral acids; dissolves in dilute solutions of alkali hydroxides. Solutions of azathioprine sodium for injection have a pH of 9.8 to 11.0; they are prepared by dissolving in Water for Injections, immediately before use. The drug is stored in airtight containers and protected from light.




Uses: Azathioprine is an immunosuppressant and antineoplastic agent. It is used in the treatment of leukaemia and mainly as an immunosuppressant for facilitating the survival of organ and tissue transplants. It is also used in lupus erythematosus, rheumatoid arthritis, renal disorders, chronic active hepatitis and some severe skin disorders.


Side Effect


The side-effects include depression of the bone marrow, gastro-intestinal disorders, joint pains, rashes, drug fever, liver damage, and pancreatitis. Solutions for injection are irritant.

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