BENZATHINE PENICILLIN



Brand Names : Benzethacil; Benzathine penicillin G; Diamine penicillin; Beacillin; Megacillin suspension; Bicillin; Cillenta; CH2 Permapen; Duropenin; Dibencillin; Penicillin; Penidural; Tardocillin; Dibencil; YNH Lentopenil; Vicin-Neolin; Pen-Di-Ben; Penidure; Moldamin; Extencilline: Longicil; Penadur; Penditan; Cepacilina .


It is the salt of a diamine, two moles of penicillin are available from each molecule of the salt. It is prepared by adding an aqueous solution of one mole N,N-dibenzylethylenediamine diacetate to an aqueous solution of moles sodium penicillin G

Benzathine penicillin G is a white odourless, tasteless, crystalline powder, m.p. 123-124°; very insoluble in water (1 g in 5000-6000 ml). This solubility property gives the compound great stability and prolonged duration of effect. It is soluble in alcohol (1 in 65); practically insoluble in chloroform and ether At the pH of gastric juice it is quite stable, and food intake does not interfere with its absorption. It is stored at a temperature not exceeding 30 in airtight containers and protected from light and moisture



Uses


1.     Benzathine penicillin has the same antimicrobial action as benzylpenicillin, but because of the relatively low blood concentrations of benzylpenicillin produced, its use should be restricted to micro-organisms that are highly susceptible to benzylpenicillin.
2.      It is used for the treatment of syphilis and other treponemal infections, such as yaws, pinta, and endemic syphilis.

3.      It may be used to cure streptococcal infections, particularly of the upper respiratory tract. It should not be given to patients suffering from gonorrhoea.'

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