Benztropine mesylate

Benztropine mesylate, m.p. 143°, is prepared by the action of diphenyldiazomethane on tropine. It is a white, odourless, slightly hygroscopic, crystalline powder; very soluble in water and alcohol; practically insoluble in ether; stored in airtight containers.




Uses:

1.     Benztropine mesylate is an anticholinergic, antihistaminic, local anaesthetic and antimuscarinic agent with actions similar to those of atropine.
2.     It also has a direct antispasmodic action on smooth muscle.
3.     It is used for the symptomatic treatment of parkinsonism and to alleviate the effect induced by drugs such as the phenothiazine derivatives.
4.     It may minimize drooling, sialorrhea, masklike facies, oculogyric crises and muscular Cramps.

Side Effect



Side effects of BENZTROPINE MESYLATE.and other antimuscarinic agents include dryness of mouth, thirst, dilation of the pupils, flushing and dryness of the skin, bradycardia, reduction of tone, constipation, etc. Sometimes vomiting, giddiness and staggering may occur. Toxic doses cause tachycardia, rapid respiration, hyperpyrexia and CNS stimulation.

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