BENZYLPENICILLIN

Brand Names : Crystalline penicilin G. Penicilin: Free penicilin G: Free penicillin II: Benzylpenicillinic acid, Free benzylpenicillin.

The name of benzylpenicillin is commonly used to describe either benzylpenicillin sodium or benzylpenicillin potassium as these are the forms in which benzylpenicillin is used. Benzyl penicillin is obtained by extraction at ice temperature of the acidified (pH2) aqueous solution of sodium benzylpenicillin with ether or chloroform. When kept dry the acid retains its antibiotic potency for limited periods, but it is rapidly inactivated by small amounts of water. The product formed on slow inactivation by moisture seems to be benzylpenicilloic acid.

Benzylpenicillin  is an amorphous white powder; sparingly soluble in water; soluble in methanol, ethanol, ether, ethyl acetate, benzene, chloroform, and acetone and insoluble in petroleum ether; m.p. 80-87. It forms methyl ester with diazomethane. It is stored at a temperature not exceeding 30* in airtight containers.



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