CARBENICILLIN SODIUM

Brand Names: BRL-2064, Carbenicillin disodium; CP-15639. 2; Anabactyl; Carbapen; Carbecin; Geopen; Hyoper; Microcillin; Pyocianil, Pyopen, Disodium a-carboxybenzyl penicilin.



Carbenicillin sodium occurs as a white hygroscopic powder. It is soluble in water (1 in 1.2) and alcohol (1 in 25); practically insoluble in chloroform and ether. A 10 per cent solution in water has a pH of 6 to 8. Aqueosis solutions of carbenicillin sodium are reported to be stable for up to 24 hours at room temperature.



Carbenicillin is not stable in acids and is inactivated by penicillinases. Carbeniclin sodium is stored at a temperature not exceeding 5* in well-closed containers.



Uses

 Carbenicillin is used in the treatment of infections due to Pseudomonas aeruginosa, infections due to non-penicillinase producing strains of Proteus species, systemic infections, respiratory -tract infections and urinary tract infections.



Adeverse Effect


Adverse effects of carbenicillin are the same as reported for benzylpenicillin sodium. Purpura and haemorrhage have been reported. Pain at the injection site and phlebitis may occur. Electrolytic disturbances, particularly hypokalaemia or hypernatraemia, may follow the administration of large doses of carbenicillin sodium. The most serious possibility being hypersensitivity reactions

Comments

Post a Comment

Popular posts from this blog

PROPANDID

PROPANDID Brand Names : Bayer-1420; FBA-1420; TH-2 180; WH-5668. Propanidid, b.p. 210-212°, is a pale greenish-yellow viscous liquid with a slight odour. It is very slightly soluble in water; miscible with alcohol, chloroform and  ether. Propanidid has been used as an  intravenous anaesthetic for rapid induction and for maintenance of anaesthesia of short duration
Read more

Vitamin A2

Vitamin A2 Vitamin A2, ( Brand Names : Retinol 2; 3,4-Didehydroretino Dehydroretinol); all trans, m.p. 17-19; 13-cis, m.p. 73-74°. is found in marine fishes of the family Labridae and in turtles. It exhibits chemical, physical and biological properties identical to vitamin A Vitamin A2 has about 40 per cent of the bioactivity of crystalline vitamin A
Read more

HOMATROPINE

HOMATROPINE Brand Names : Mandelyltropeine, Tropine mandelate. Homatropine is a synthetic alkaloid which is a lower homologue of atropine. It is prepared by the interaction of tropine and mandelic acid. Homatropine, m.p. 99-100°, occurs as colourless, odourless crystals or a white crystalline powder. It is hygroscopic, but only slightly soluble in water; soluble in alcohol, benzene, chloroform, ether, acetone and dilute acids. The hydrobromide or hydrochloride is obained readily from the free base by neutralizing with hydrobromic or hydrochkoric acid. The hydrobromide occurs as colourless, odourless crystals or a white crystalline powder. It is soluble in water and alcohol; slightly soluble in chloroform; very slightly soluble in ether; stored in airtight containers and protected from light. Homatropine methylbromide, m.p. 210-212°, is the tropine methylbromide ester of mandelic acid. It is prepared by treating homatropine with methyl bromide, thus yielding the ...
Read more