CHLORAMBUCIL



Chlorambucil, m.p. 64-66, is a white or off-white crystalline or granular powder. It is practically  insoluble in water; soluble in alcohol, acetone, chloroform and dilute solutions of alkali hydroxides. It is stored in airtight containers and protected from light. –


Uses : Chlorambucil is an antineoplastic agent and is most valuable in lymphocytes. It is used in the treatment of chronic lymphocytic leukaemia, Hodgkin's disease, incarcinoma of the breast, ovary and testes.


Side Effect

The side-effects include bone-marrow depression, gastrointestinal disorders, hepatotoxicity, skin rashes, central neurotoxicity, including seizures, interstitial pneumonia and pulmonary fibrosis.




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