CHLORDIAZEPOXIDE



Brand Names : Metaminodiazepoxide; Methaminodiazepoxide; Libritabs; Menrium; Mesural; Multum; O.C.M.; Risolid; Silibrin; Sonimen; Tropium; Zeisin; Zetran

Chlordiazepoxide is a derivative of 1,4-benzodiazepine.It was synthesized by Sternbach and co-workers from p-chloroaniline:
Chlordiazepoxide is a light yellow compound, m.p. 236237, used as hydrochloride; stored in airtight containers and protected from light.

Chlordiazepoxide hydrochloride (Brand Names : Ansiacal; Bent: Benzodiapin; Calmoden; Cebrum: Chlordiazachel: Corax, Diazachel, Droxol; Elenium, Equibral; J-Liberty; Kalimocaps; Labican, Lentoran, Librium, Mildmen; Napton; Novosed; Psichial; Psicosan; Psicoterina; Reliberan; Sophiamin; Seren vita; SKLygen; Tensinyl; Timosin; Trakipeal, Viansin; Viopsicol).

Chlordiazepoxide hydrochloride is a colourless crystalline substance, light sensitive and highly soluble in water but unstable in aqueous solution due to hydrolysis to the lactam, an amino acid and finally 2-amino-5-chlorobenzophenone.


These are the major metabolites of chlordiazepoxide, all primarily excreted in the urine. The decomposion products are ' detected on silica gel thin-layer chromatography.

On exposure to light, chlordiazepoxide hydrochloride undergoes the nitrone rearrangement to give a 4, 5-epoxide:

Uses: Chlordiazepoxide has psychosedative properties used as sedative and minor tranquillizer. Its abuse may lead to habituation or addiction.




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