CHLORPHENIRAMINE MALEATE


Brand Names : Allerclor; Allergisan; Alunex; Antagonate; Chlormene; Chlor-Trimeton; Chlor-Tripolon; Cloropiril; C-Meton; Histadur; Histalen; Histaspan; Lorphen; M.P. Chlorcaps T.D.;




Piriton; Polaronil (Germany), Pyridamal-100; Teldrin); m.p. 130135°, is a white, odourless crystalline powder. It is soluble in water, alcohol and chloroform; slightly soluble in ether. A 196 solution in water has a pH 4.0 to 5.0. The drug is stored airtight containers and protected from light.



Chlorpheniramine is one of the most potent oral antihistamines. The presence of chlorine group of pheniramine in the p-position of the phenyl ring increases 20-fold potency with no appreciate change in toxicity.



Uses : Chlorpheniramine is an outstanding antihistaminic agent which exerts useful protection and causes a moderate degree of sedation. In severe allergies it may be given by injection which may be irritant and transient hypotension or stimulation of the CNS may occur during rapid intravenous injection.


Comments

Post a Comment

Popular posts from this blog

PROPANDID

PROPANDID Brand Names : Bayer-1420; FBA-1420; TH-2 180; WH-5668. Propanidid, b.p. 210-212°, is a pale greenish-yellow viscous liquid with a slight odour. It is very slightly soluble in water; miscible with alcohol, chloroform and  ether. Propanidid has been used as an  intravenous anaesthetic for rapid induction and for maintenance of anaesthesia of short duration
Read more

ΒΙΟΤΙΝ

ΒΙΟΤΙΝ Brand Names : Vitamin H; Coenzyme R; Bios II; Bioepiderm; Anti-Egg white injury Factor; S/Skin Factor. Biotin is the growth factor present in minute amounts in every living cells. It plays an indispensable role in numerous naturally occurring carboxylation reactions. It occurs mainly bound to proteins or polypeptides. The richest sources are liver, kidney, pancreas, yeast and milk. The biotin content of cancerous tumors is higher than that of normal tissue. Biotin combines with the proteinaceous substance, avidin, in egg-white and becomes inactive. Biotin, m.p. 232-233°, is a white, crystalline powder which is very slightly soluble in water and in alcohol; insoluble in other common organic solvents; more soluble in hot water and in dilute alkali. The pure compound is stable to air and temperature; moderately acid and neutral solutions are stable for several months; alkaline solutions are less stable. Aqueous solutions are very susceptible to mold growth . Biotin ...
Read more

HOMATROPINE

HOMATROPINE Brand Names : Mandelyltropeine, Tropine mandelate. Homatropine is a synthetic alkaloid which is a lower homologue of atropine. It is prepared by the interaction of tropine and mandelic acid. Homatropine, m.p. 99-100°, occurs as colourless, odourless crystals or a white crystalline powder. It is hygroscopic, but only slightly soluble in water; soluble in alcohol, benzene, chloroform, ether, acetone and dilute acids. The hydrobromide or hydrochloride is obained readily from the free base by neutralizing with hydrobromic or hydrochkoric acid. The hydrobromide occurs as colourless, odourless crystals or a white crystalline powder. It is soluble in water and alcohol; slightly soluble in chloroform; very slightly soluble in ether; stored in airtight containers and protected from light. Homatropine methylbromide, m.p. 210-212°, is the tropine methylbromide ester of mandelic acid. It is prepared by treating homatropine with methyl bromide, thus yielding the ...
Read more