CHLORPROPAMIDE



Brand Names : P-6O7; Adiaben; Asucrol; Catanil; Chloronase; Diabechlor; Dia benal; Diabetoral; Dia binese; Melitase; Millinese; Oradian; methy Stabinol.



hlorpropamide, m. p. 127-129°, is a derivative of ben- 2043; zenesulphonamide. It is synthesized from chloro-benzene, which, Diasu on treatment with chlorosulphonic acid, yields 4- Orina chlorobenzenesulphonyl chloride. Reaction with excess of Diab ammonia forms the sulphonamide, which is refluxed with ethyl Oterb chloroformate to produce ethyl N-4-chlorophenylsulphonyl- The substituted urothane on condensation with N-propylamine forms chlorpropamide.
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Chlorpropamide is a white, odourless, crystalline powder which is soluble in water at pH 6, practically insoluble at pH 7.3; in alcohol; moderately soluble in chloroform; sparingly soluble in ether and benzene.



Uses: Chlorpropamide is a sulphonylurea hypoglycaemic agent which is used in the treatment of non-insulin-dependent diabetes mellitus.



Side Effect

The side-effects include gastro-intestinal disturbances such as nausea, vomiting, heartburn, anorexia, constipation, diarrhoea, and metallic taste. They may also cause headache, dizziness, weakness, paraesthesia, and tinnitus.





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