CLOXACILLIN SODIUM



Brand Names : Sodium cloxacillin; BRL-1621; Bactopen; Cloxapen; Cloxypen; Ekvacillin; Gelstaph; Orbenin; MethocillinS; Prostaphlin-A; Staphobristol-250°; Staphybiotic; Tegopen;
Cloxacillin sodium, m.p. 170° (decomp), occurs as a white, odorless, hygroscopic, micro-crystalline powder. It is soluble in water (1 in 2.5 ), alcohol (1 in 3O), methanol, pyridine and ethylene glycol; slightly soluble in chloroform.JA 10 per cent solution in water has a pH of 5 to 7. Aqueous solutions of cloxacillin sodium are reported to be stable for up to 24 hours at 25°C and for up to 72 hours at 5°. Cloxacillin sodium is stored at a temperature not exceeding 25 in airtight containers.

Uses
Cloxacillin is an isoxazolyl penicillin used to treat infections due to Staphylococci resistant to benzylpenicillin, including infections of the skin and soft tissues, bones and joints, respiratory tract and urinary tracts; otitis media, endocarditis; septicaemia, and meningitis. It is used for the prophylaxis of staphylococcal infections during major surgical procedures, particularly in cardiothoracic and orthopaedic surgery .



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