CORTISONE

CORTISONE

Brand Name  : Kendall's Compound E; Wintersteiners Compound F; Reichstein's Substance Fa; KE; Incortin: Cortone; Cortadren; Scheroson; Corlin; Cortogen; Adreson

Cortisone may be prepared by partial or total synthesis starting from ergosterol, progesterone and sapogenins

Cortisone, m.p. 220-224°, occurs as platelets. It is fairly soluble in cold methanol, ethanol, acetone; much less soluble in ether, benzene, chloroform; slightly soluble in water. It gives orange-red solution with intense green fluorescence in concentrated sulphuric acid. It is used primarily as the 21-acetate due to its increased stability.


Cortisone Acetate (Brand Names: Cortistab; Cortelan; Cortisyl artriona; Compound E acetate; Cortogenacetate), mp 235-238, is a white, odourless, crystalline powder. It is practically insoluble in water; soluble in alcohol, acetone, chloroform and dioxane; slightly soluble in ether and methyl alcohol. It reduces ammonical silver nitrate solution at room temperature. Solution in sulphuric acid gives a yellow solution without fluorescence. It is kept in well-closed containers and protected from light.


Uses:

It Betamethasone is a glucocorticoid used as antiinflammatory and immunosuppressant glucocorticoid agent. Cortisone acetate has been used in the treatment of many allergic and inflammatory disorders. It is given in the treatment of rheumatoid arthritis including gouty arthritis, ulcerative colitis, regional enteritis, nephrotic syndrome, scleroderma dermatomyositis, psoriasis, periarteritis nodosa, pulmonary granulomatosis and alcoholism.




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