CYCLOBARBITONE

CYCLOBARBITONE



Brand Names : Cyclobarbital, Hexemal; Tetrahydrophenobarbital; Cavonyl; Cyclodorm; Cyklodorm; Fanodormo; Irifan; Namuron; Palinum; Phanodorm; Phanodorn; Philodorm; Pralumin; Pro-Sonil; Sonaform.




Cyclobarbitone contains a cyclohex-1- enyl group in the 5-position. It is prepared by condensing ethyl cyanoacetate with cyclohexanone in the presence of sodium ethoxide or pyridine to yield ethyl cyclohex1'-enylcyano acetate. With sodium ethoxide and ethyl iodide this ester is alkylated to give ethylcyanoethylacyclohex-1'-enylacetate. This reactive cyano-ester is condensed with urea to form an open-chain cyanoureide. Hydrolysis of the -CN group afforded an acid which cyclizes spontaneously to cyclobarbitone.




It occurs as shiny crystals, insipid bitter taste, m.p. 171174; very slightly soluble in cold water, appreciably soluble in hot water. One gram dissolves in 5 ml alcohol, and 20 ml ether. It is stored in airtight containers.


Uses : It has central depressant (hypnotic, sedative) activity used as an anaesthetic and sedative.




Cyclobarbitone Calcium : (Brand Names : Hexemal calcium; Itridal, Kollerdormfix; Pronox; Cyclobarbital calcium) is a white or slightly yellowish, crystalline powder. It is slightly soluble in water and alcohol; practically insoluble in chloroform and in ether; stored in airtight containers; used as hypnotic and sedative.




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