CYCLOPHOSPHAMIDE

CYCLOPHOSPHAMIDE


Brand Names: Cyclophosphane; Cytophosphane; B518; Cytoxan; Endoxan; Procytox; Sendoxan.
Cyclophosphamide, m.p. 41-45°, is a fine, white crystalline powder. It liquefies upon loss of its water of crystallization. It is soluble in water, alcohol, benzene,ethylene glycol, carbon tetrachloride, dioxane; sparingly solub in ether and acetone.



Uses: Cyclophosphamide is an antineoplastic agent which has marked immunosuppressant properties. It is used in the treatment ofa variety of malignant diseases including Burkitt's lymphoma. Hodgkin’s disease, leukaemia, myeloma and mycosis fungoides. It is also used in the treatment of various solid tumours such as tumours of the breast, cervix, lung and ovary.

Side Effect

Leucopenia, urinary complications, alopecia, hyper pigmentation of skin, gastro-intestinal disorders, hepatotoxicity, disturbance of carbohydrate metabolism and secretion of antidiuretic hormone, etc, are some side-effects of cyclophosphamide therapy.


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