CYPROHEPTADINE

CYPROHEPTADINE

Brand Name : Periactinol.

Cyproheptadine is synthesized from a ketone consisting of two benzene rings fused in a linear fashion to a seven membered ketone. It is first brominated with N- bronosuccinimide (NBS) and then dehydrobrominated by treatment with  triethylamine. The product is reacted with the Grignard reagent, N-methyl-4-piperidyl magnesium chloride, to yield a complex. This is dehydrated by solution in acetic acid and then treated with hydrogen chloride and acetic anhydride to yield cyproheptadine hydrochloride.

Cyproheptadine, m.p. 112-114, is a crystalline compound.

Cyproheptadine hydrochloride (Brand Names : Anarexol; Antegan; Ifrasarl; Nuran; Periactin; Vimicon; Cipractin; Peritol), Imp. 252-254 (decomp), is a white to slightly yellow, odourless, crystalline powder which is soluble in water, alcohol, methanol and chloroform; practically insoluble in ether.

Uses: Cyproheptadine is an antihistamine, antiserotonin and antipruritic agent. It has antimuscarinic activity and is used to suppress the symptoms of allergic reactions and is effective in cold urticaria . It is also used as an appetite stimulant, in eatment of vascular and migraine headaches, Cushings disease and allergic conditions and to relieve various itching skin conditions.

Side Effect
The side effects are the same as for promethazine. Increased appetite and weight gain may occur.






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