DAUNORUBICIN



Brand Names : Daunomycin; Leukaemomycin C; Rubido-mycin; Cerubidin.



Daunorubicin is a glycoside formed by a tetracyclic aglycone, daunomycinone (C21, H18, O8,) and an amino sugar, daunosamine (C6H13 NO). It is an antineoplastic produced by Streptomyces coeruleo rubidus or S. peucetitus.



Daunorubicin Hydrochloride



Brand Names : Cerubidine; Daunoblastina; Ondena), 


m.p. 188-1909 (decomp), occurs as thin red needles.


 It is soluble in water, methanol, aqueous alcohols; practically insoluble in chloroform, ether and benzene. Colour of aqueous solution changes from pink at acid pH to blue at alkaline pH.



Uses : Daunorubicin is an antineoplastic antibiotic agent. Its drochloride is given in association with vincristine and prednisone in acute lymphoblastic leukaemia. Cardiotoxicity is more likely when the total dose of daunorubicin exceeds 500 mg in adults.


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