DEMECLOCYCLINE

DEMECLOCYCLINE

Brand Name : RP 10192; Bioterciclin; Declomycin; Deganol; Ledermycin; Periciclina




Demeclocycline hydrochloride is an antimicrobial substance produced by the growth of certain strains of Strepomyces aureofaciens and firstisolated by McCormicket al. (1957). 



It differs from chlortetracycline only by the absence of the methyl group on carbon atom 6. The stability of ring C is enhanced to both acid and alkali due to the absence of this methyl group. It occurs as a yellow, odourless, crystalline powder. It is slightly solubleinwater (1 in 30-60), methylalcohol (1 in 50), and alcohol; practically insolubleinacetone, chloroform, and ether; soluble in aqueous solutions of alkalihydroxides and carbonates. Similar to the other tetracyclines, it may cause infrequent photosensitivity reactions.


Demeclocycline hydrochloride (Brand Names: Clortetrin; Demetraciclina; Detravi's Meciclin; Mixocine). Demeclocycline and its salts are kept in airtight containers and protected from light.



Uses:

 Demeclocycline has the antimicrobial activity and uses described for tetracycline hydrochloride. It is excreted more slowly and effective blood concentrations are maintained for a longer period.


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