DEXTROPROPOXYPHENE

DEXTROPROPOXYPHENE

Brand Names : d-Propoxyphene



This aliphatic tertiary amine base is also an arylsubstituted aliphatic ester of propionic acid. The substituted isobutyro-phenone required for its synthesis can be prepared by condensation of propiophenone, paraformaldehyde and diethylamine hydrochloride (Mannich reaction). The aminoketone so obtained reacts with the Grignard reagent, benzyl magnesium chloride, which on hydrolysis gives mainly the form of a tertiary alcohol hydrochloride. This alcohol is esterified by refluxing with propionic anhydride in the presence of pyridine.

Dextropropoxyphene. m.p. 75-76°, occurs as crystals.


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