DI-IODOHYDROXYQUINOLINE

DI-IODOHYDROXYQUINOLINE

Brand Names: Diiodohydroxyquin, Di-iodohydroxyquinoline; Di-iodoxychinolinum; Di-iodoquinoline; Iodoquinol; Diiodoquin

            The compound is the 5,7-di-iodo derivative of 8hydroxyquinoline, from which it is prepared by directiodination by the action of iodine monochloride or potassium iodate. The iodine atoms enter the activated benzenoid ring in the positions ortho-and para-to the directing -OH group.

The compound is a light yellowish to tan-coloured, microcrystalline powder, odourless powder, not readily wetted in water. Practically it is insoluble in water; sparingly soluble in alcohol and ether.


Uses

Di-iodohydróxyquinoline is a luminal amoebicide acting principally in the bowel lumen and is used in the treatment of intestinal amoebiasis. It is given alone in the treatment of asymptomatic cyst-passers. It is also given in the treatment of balantidiasis and the infestation by Trichomonas hominis (intestinalis). It has anti-bacterial and anti-fungal activity and has been used topically in various skin conditions, usually along with a corticosteroid

Adverse Effect

In high doses for long term, the adverse effects are optic neuritis, optic atrophy, peripheral neuropathy, gastro-intestinal effects such as abdominal cramps, nausea, and diarrhoea. Other side-effects are the same as for iodochlorhydroxyquin.


Comments

Post a Comment

Popular posts from this blog

PROPANDID

PROPANDID Brand Names : Bayer-1420; FBA-1420; TH-2 180; WH-5668. Propanidid, b.p. 210-212°, is a pale greenish-yellow viscous liquid with a slight odour. It is very slightly soluble in water; miscible with alcohol, chloroform and  ether. Propanidid has been used as an  intravenous anaesthetic for rapid induction and for maintenance of anaesthesia of short duration
Read more

Vitamin A2

Vitamin A2 Vitamin A2, ( Brand Names : Retinol 2; 3,4-Didehydroretino Dehydroretinol); all trans, m.p. 17-19; 13-cis, m.p. 73-74°. is found in marine fishes of the family Labridae and in turtles. It exhibits chemical, physical and biological properties identical to vitamin A Vitamin A2 has about 40 per cent of the bioactivity of crystalline vitamin A
Read more

HOMATROPINE

HOMATROPINE Brand Names : Mandelyltropeine, Tropine mandelate. Homatropine is a synthetic alkaloid which is a lower homologue of atropine. It is prepared by the interaction of tropine and mandelic acid. Homatropine, m.p. 99-100°, occurs as colourless, odourless crystals or a white crystalline powder. It is hygroscopic, but only slightly soluble in water; soluble in alcohol, benzene, chloroform, ether, acetone and dilute acids. The hydrobromide or hydrochloride is obained readily from the free base by neutralizing with hydrobromic or hydrochkoric acid. The hydrobromide occurs as colourless, odourless crystals or a white crystalline powder. It is soluble in water and alcohol; slightly soluble in chloroform; very slightly soluble in ether; stored in airtight containers and protected from light. Homatropine methylbromide, m.p. 210-212°, is the tropine methylbromide ester of mandelic acid. It is prepared by treating homatropine with methyl bromide, thus yielding the ...
Read more