DIETHYLCARBAMAZINE (D.E.C)

DIETHYLCARBAMAZINE (D.E.C)

Brand Names : Carbamazine, 84L; RP 3799; Banocide; Carbilazine; Caricide; Cypip; Ethodryl; Notezine; Spatonin; Hetrazan.

Diethylcarbamazine, which is 1-diethyl CH3 2 carbamoyl-4-methylpiperazine, is prepared by condensingpiperazine with diethylcarbamoyl chloride. (prepared from diethylamine and carbonyl chloride) and then methylating the other nitrogen atom with formaldehyde.

Diethylcarbamazine, m.p. 47-49, is a crystalline compound. Its-hydrochloride is very soluble in water; soluble in chloroform and dioxane.

Diethylcarbamazine Citrate (Brand Names: Franocide: Filazine; Loxuran; Longicid; Dirocide; Filaribits; Hetrazan), m.p. 141 - 143°, is a colourless, crystalline solid; freely soluble in water; sparingly soluble in cold alcohol; practically insoluble in benzene, acetone, ether, and chloroform. A 1 per cent solution has a pH of 4.1. The drug is stable under various climatic conditions and moisture. It is stored in airtight containers. Solution should be protected from light.


Uses : Diethylcarbamazine is used as an anthelmintic and antifilarial agent .



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