DILOXANIDE FUROATE

                DILOXANIDE FUROATE

Brand Names: Miforon; Diloxanide 2-furoic acid ester; Furamide: Histonnibal.


Diloxanide furoate is an aromatic ester of 2-furoic acid. For its synthesis, 4-aminophenol is treated with chloral cyanohydrin in the presence of pyridine and triethylamine. The resulting phenol is then benzoylated before methylation of the amido group, followed by hydrolysis with 0.5 N sodium hydroxide to give diloxamide. Esterification of diloxanide with furoyl chloride yields diloxanide furoate.

Diloxanide furoate is a white, odourless, crystalline powder; very slightly soluble in water; slightly soluble in ether and alcohol. It is protected from light .

Uses

It is a luminal amoebicide used in the treatment of intestinal amoebiasis. With metronidazole it is used to treat Entamoeba polecki infection.

Adverse effect

Flatulence is the most common adverse effect during treatment with diloxanide furoate. Vomiting, pruritis and urticaria may occasionally occur.




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