Doxycycline hydrochloride

Doxycycline hydrochloride

Brand Names : Doxycycline hydrate; Vibramycin hydrate; DoxyII (Caps); Doxy-Tablinen; Vibra-Tabs; Retens; Nivocilin; Tenamicin; Tatradox; Hydromycin; Doxigalumicina; Tecacin, Mespafin, Roximycin.

Doxycycline hydrochloride occurs as a yellow hygroscopic crystalline powder which crystallizes from ethanol and hydrochloric acid mixture)It chars without melting at about 201°. It is biologically more active than the corresponding 6pepimer hydrochloride.


Doxycycline hydrochloride is soluble in water (1 in 3) and methyl alcohol (1 in 4); sparingly soluble in alcohol; practically insoluble in chloroform and ether; soluble in solutions of alkali hydroxides and carbonates. Doxycycline and its salts are stored in airtight containers and protected from light.

Uses



Doxycycline hydrochloride is used for the same purposes as tetracycline hydrochloride. It is readily absorbed and excreted more slowly than most other tetracyclines and effective blood concentrations are maintained for longer periods. The adverse effects as the same as for tetracycline hydrochloride



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