EPHEDRINE

EPHEDRINE



Brand Names : Hydrated Ephedrine; Efedrina; Ephedrinum.


Ephedrine is an alkaloid obtained from the Eastern drug, Ma Huang (Ephedra vulgaris, E. sinica; E. equisetina; Family Gnetaceae). 


It has two asymmetric carbon atoms; thus there are four optically active structures. Isomeric forms include d- and 1-ephedrineas well as d- and - pseudoephedrine. The l-ephedrine and d-pseudoephedrine are the naturally occurring
isoners


Ephedrine is a colourless crystalline powder, m.p. 79; soluble in water, alcohol, ether, chloroform and oils. In light it gradually decomposes and darkens. Ephedrine hyedrochloride, m.p. 187-1889 and ephedrine sulphate, m.p. 247, are white odourless crystalline powders, soluble in water and alcohol: both are effected by light. The drug is stored at a temperature not exceeding 8* in airtight containers and protected from light.

Uses : Epidhrine a sympathomimetic agent , has been used to counteract hypotension associated with anaesthesia; as a mydriatic; in allergic reactions and as a CNS stimulant. Ephedrine salts have been used in the symptomatic relief of nasal congestion  associated with the common cold, hay-fever, sinusitis.



Adverse Effect

Adverse effects of ephedrine are the same as described under adrenaline.


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