ETHACRYNIC ACID

ETHACRYNIC ACID


Brand Names : MK-595; Crinuryl; Edecril; Edecrin; Endecril; Hydromedin; Reomax: Taladren; Uregit.


Ethacrynic acid, m.p. 121-120°, is an unsaturated derivative of a dichlorophenoxyacetic acid. It is a white, odourless, crystalline powder; sparingly soluble in water; soluble in alcohol,chloroform and ether; dissolves in ammonia and in dilute aqueous solutions of alkali hydroxides carbonates; stored in airtight containers. Sodium salt, called ethacrynate sodium or Lyovac sodium edecrin, is soluble in Water.

Uses : Ethacrynic acid is a diuretic and used similarly to chlorothiazide.




Side Effect

The side effects of ethacrynic acid are fluid and electrolyte imbalance, hyponatraemia, hypokalaemia, gastro-intestinal disturbances, hypochloremic, alkalosis, and deafness in patients with uremia. Other adverse effects include confusion, fatigue, nervousness, and apprehensiveness.


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