ETHAMBUTOL

ETHAMBUTOL

Brand Names : Dadibutol, EMB; Sural; Tibutol; Myambutol; Ebutol; Etambol.


It is a white, odourless, crystalline powder freely soluble in waterti.l), alcohol (1.4); slightly soluble in chloroform; practically insoluble in ether; m.p. 87-89. )


Ethambutol is stereospecific in activity. The dextro isomer is 16 times as active as the meso isomer and the laevo isomer is even less active than the meso isomer.


Uses :


 Ethambutol hydrochloride is used with other antituberculous agents in the treatment of tuberculosis. It is rapidly absorbed after oral administration. Many patients cannot tolerate therapeutic doses of ethionamide and have to discontinue treatment. The most common adverse effects are dose-related : gastro-intestinal disturbances, including anorexia, excessive salivation, a metallic taste, nausea, vomiting, stomatitis, and diarrhoea. Dizziness, drowsiness, headache, postural hypotension, and asthenia may also occur occasionally. Although jaundice is rare, hepatitis may occur in about 5% of patients receiving ethionamide

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