EVANSBLUE

EVANSBLUE



Brand Names : C.I. Direct Blue 53; C.I. 23860; T-1824; Azovan Blue.



Evans blue is an azo-dye ofdiagnostic value and is prepared by coupling tetrazotized o-tolidine with 2 moles of Chicago acid (8-amino-1-hydroxy-5,7-naphthalenedisulphonic acid) in alkaline solution.



Evans blue is green, bluish-green or brown, odourless powder. It is very soluble in water; very slightly soluble in alcohol; practically insoluble in carbon tetrachkoride, chloroform and ether; at pH 10 the colour is changed. It is destroyed by strong oxidizing and reducing agents and precipitated from saturated solution of neutral salts. It is rather stable in aqueous solution. and may be autoclaved at l5 lbs pressure for 30 minutes. The aqueous solutions are quite stable and may be autoclaved. Saline solutions are less stable and should not be autoclaved.


In body Evans dye combines firmly with the plasma albumin. The colour developed is directly proportional to its concentration.


Uses : Evans dye is used for the determination of blood (or plasma) volume. A quantitative amount of the dye is injected intravenously. After a suitable interval a sample of blood is taken, and the dye in the plasma is determined colorimetrically. The dye does not escape into the extracellular fluid and is only slowly excreted via the kidneys.


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