FLUORESCEIN SODIUM

FLUORESCEIN SODIUM

Brand Nannes : Soluble fluorescein; Resorcinol Phthalein sodium; Uranin(e); Uranine yellow; D&C yellow No.8; C.I.Acid yellow 73; C.I. No. 45350; COONa Funduscein; Resorcinolphthalein sodium; Soluble fluorescein.



Fluorescein is a dye of the phthalein group. It is prepared by condensing phthalic anhydride with resorcinol by melting the two substances together in the presence of anhydrous zinc chloride or other suitable condensing agent.


Fluorescein occurs as red, sparingly soluble crystals. It dissolves freely in aqueous sodium hydroxide, forming a sodium salt. Fluorescein sodium is a disodium salt which occurs as an orange-red, odourless, hygroscopic powder.


It is soluble in water with yellow-red colour and intense yellowish-green fluorescence. The fluorescence disappears when the solution is made acidic and re-appears when the solution is again made neutral or alkaline. It is kept in airtight containers and protected from light.

Uses:

Sodium fluorescein is used as an ophthalmologic diagnostic agent for detecting corneal lesions and foreign bodies. It is used as an aid to the fitting of hard contact lenses and to differentiate healthy tissues from diseased or damaged tissues.


Side Effect

The intravenous injection of fluorescein sodium may produce nausea and vomiting. Allergic reactions may consistofurticaria. The skin and urine may be coloured yellow but that is transient. Patients may also experience an unpleasant taste.




Comments

Post a Comment

Popular posts from this blog

PROPANDID

PROPANDID Brand Names : Bayer-1420; FBA-1420; TH-2 180; WH-5668. Propanidid, b.p. 210-212°, is a pale greenish-yellow viscous liquid with a slight odour. It is very slightly soluble in water; miscible with alcohol, chloroform and  ether. Propanidid has been used as an  intravenous anaesthetic for rapid induction and for maintenance of anaesthesia of short duration
Read more

Vitamin A2

Vitamin A2 Vitamin A2, ( Brand Names : Retinol 2; 3,4-Didehydroretino Dehydroretinol); all trans, m.p. 17-19; 13-cis, m.p. 73-74°. is found in marine fishes of the family Labridae and in turtles. It exhibits chemical, physical and biological properties identical to vitamin A Vitamin A2 has about 40 per cent of the bioactivity of crystalline vitamin A
Read more

HOMATROPINE

HOMATROPINE Brand Names : Mandelyltropeine, Tropine mandelate. Homatropine is a synthetic alkaloid which is a lower homologue of atropine. It is prepared by the interaction of tropine and mandelic acid. Homatropine, m.p. 99-100°, occurs as colourless, odourless crystals or a white crystalline powder. It is hygroscopic, but only slightly soluble in water; soluble in alcohol, benzene, chloroform, ether, acetone and dilute acids. The hydrobromide or hydrochloride is obained readily from the free base by neutralizing with hydrobromic or hydrochkoric acid. The hydrobromide occurs as colourless, odourless crystals or a white crystalline powder. It is soluble in water and alcohol; slightly soluble in chloroform; very slightly soluble in ether; stored in airtight containers and protected from light. Homatropine methylbromide, m.p. 210-212°, is the tropine methylbromide ester of mandelic acid. It is prepared by treating homatropine with methyl bromide, thus yielding the ...
Read more