FLUOROURACIL

FLUOROURACIL


Brand Names : Ro 2-9757; NSC 19893; Adrucil; . 5-Fu; Arumel; Efudex; Efudix; Fluril; Fluracil; Fluoroplex: Fluro uracil; Timazin.



Fluorouracil, a pyrimidine analogue, m. p. F 282-283 (decomp), is a white, odourless, 0 crystalline powder. It is sparingly soluble in water; slightly soluble in alcohol; practically insoluble in chloroform and ether. A 1 per cent solution has a pH of 4.3 to 5.3.






Uses : Fluorouracilis an antineoplastic agent which is used in malignant neoplasms, especially those of the gastro-intestinal tract, breast, liver, genito-urinary system, and pancreas.




Side Effect

The main adverse effects of fluorouracil are on the bone marrow and the gastro-intestinal tract. Leucopenia, stomatitis, gastro-intestinal ulceration, bleeding and severe diarrhoea are signs that treatment should be stopped.



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