FOLINIC ACID --SF

FOLINIC ACID --SF





Folinic acid is an intermediate product of the metabolism of folic acid; the active form into which that acid is converted in the body, ascorbic acid being a necessary factor in the conversion process. Folinic acid and not folic acid is the natural factor in digests of liver and that folic acid arises from folinic acid. Folinic acid can be prepared from folic acid by formylation, reduction and autoclaving or the action of dilute alkali. It also can be prepared by the formylation of tetrahydrofolic acid.



Folinic acid occurs as crystalline material, m.p. 240-250°. It is sparingly soluble in water; pH of saturated aqueous solution is 2.8-3.0 at which pH partial decomposition takes place. It is more stable at neutral or mildly alkaline pH.



Calcium Folinate (Brand names : Calcium Leucovorin; NS3590; Leucovorin calcium) is a yellowish-white or yellow, odourless powder. It is very soluble in water; practically insoluble in alcohol; protected from light..



Uses: Folinic acid is used as an antidote to folic acid antagonists. such as methotrexate. It is effective in the treatment of megaloblastic anaemia.






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