GLYCERYL TRINTRATE

GLYCERYL   TRINTRATE

Brand Names : Nitroglycerine; Trinitroglycerol; Trinitrin; Glonoin: Blasting gelatin; Blasting oil; S.N.G.; Angibid.; Angiolingual; Anginine; Angorin; Cardamist; Corditrine; Gilucor "nitro'; Klavikordal, Lenitral: Myoglycerin: Nitrobid. Nitrodisc: NitroDur; Nitroglin; Nitroglyn: Nitrolan; Nitrolar; Nitro-lent: Nitrolingual; Nitro Mack; Nitromel; Nitronal; Nitrong; Nitro PRN; Nitrorectal; Nitroretard; Nitrostat; Nitrozellretard; Nysconitrine; Percutol; Perlingant; Perglottal; Transderm-Nitro; Suscard; Sustac; Tridil; Trinalgon; Trinitrosan; Vasogyn.

Glyceryl trinitrate is the glyceride of nitric acid. It is prepared by slowly adding glycerol to an ice-cold mixture of concentrated nitric acid and concentrated sulphuric acid in the ratio of 1:4. The solution is carefully passed into ice-cold water when the glyceryl trinitrate is separated as a heavy oil. It is purified by repeated washing with cold water.

Glyceryl trinitrate is a heavy, pale yellow, oily, inflammable, explosive liquid with sweet burning taste. It produces headache on tasting and explodes on rapid heating or when struck with hammer. In impure form it may explode spontaneously. It is slightly soluble in water; soluble in methyl alcohol, alcohol, carbon disulphide, acetone, chloroform, ether and in glacial acetic-acid.

Concentrated glyceryl trinitrate is a 9-11% solution of glyceryl trinitrate in alcohol (96%). Dilute nitroglycerin is a mixture of glyceryl trinitrate with lactose, glucose, alcohol, propylene glycol or other suitable inert excipient.

Uses
Glycery trinitrate relaxes smooth muscles, including vascular muscles and reduces the blood pressure. It is used as a vasodilator in the prophylaxis and treatment of angina pectoris; for bronchial asthma în dogs.

Adverse Effect

Adverse effects of glyceryl trinitrate are acute poisoning, occurring in industrial workers; nausea, vomiting, abdominal cramps, headache, mental confusion, delirium, bradypnea, bradycardia, paralysis, convulsions, methemoglobinemia, cyanosis, circulatory collapse and death.





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