GRISEOFULVIN

GRISEOFULVIN




Brand Names : Amudane; Curling factor; Fulcin; FutVicin; Grifulvin; Grisactin; Grisovin; Gris-PEG; Grysio; Lamoryl; Likuden; Neo-Fulcin;Poncyl; Spirofulvin; Sporostatin.



Griseofulvin in an antifungal substance produced by the growth of certain strains of Penicillium griseofulvum. It is a white, or yellowish-white, bitter, odourless, thermostable powder that may be crystallized as needles, m.p. 220°. It is insoluble in water; slightly soluble in alcohol and in methyl alcohol; soluble in chloroform; freely soluble in dimethylformamide and in tetrachloroethane. In dried state it is stable for at least 20 months. It is stored in well-closed containers .


Uses:

Griseofulvin is administered by mouth in the treatment of tinen (ringworm) infections. It is given for infections of the scalp, hair, and nails, and for infections of the skin which do not respond to topical treatment. 


Side Effect


Side-effects are usually mild and transient and consist of mainly of headache, skin rashes, dryness of the mouth, an altered sensation of taste, and gastro-intestinal disturbances. Angioedema, erythema multiforme, exfoliative dermatitis, proteinuria, leucopenia and other blood dyscrasias, candidiasis, paraesthesia, photosensitisation, and severe headache have been reported occasionally. Depression, confusion, dizziness, insomnia, and fatigue have also been reported .


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